Cell mediated immunity vs Humoral immunity

Cell mediated immunity vs Humoral immunity

Cell mediated immunity vs Humoral immunity

Cell-mediated immunity:

  • It is mediated by both activated TH cells and CTLs.
  • Cytokines secreted by TH cells activate various phagocytic cells, enabling them to phagocytose and kill microorganisms.
  • This type of cell-mediated immune response is especially important against a host of bacterial and protozoal pathogens.
  • CTLs play an important role in killing virus-infected cells and tumor cells.

Humoral immunity:

  • It is mediated by molecules in the blood and mucosal secretions called antibodies.
  • The antibodies are secreted by a subset of lymphocytes known as B cells.
  • The antibodies recognize microbial antigens, combine specifically with the antigens, neutralize the infectivity of microbes, and target microbes for elimination by various effector mechanisms.
  • Humoral immunity is the principal defense mechanism against extracellular microbes.

Cell mediated immunity vs Humoral immunity

Cell-mediated immunity Humoral immunity
Immune response mediated by cells Immune response mediated by antibodies
Protects against fungi, viruses, and facultative intracellular bacterial pathogens Protects against extracellular bacterial pathogens and viruses infecting respiratory or intestinal tract; and prevents recurrence of viral infections
Mediates delayed (type IV) hypersensitivity Mediates immediate (types I, II, and III) hypersensitiviy
Only T-cell-dependent antigens lead to cell mediated immunity B cells directly bind soluble antigens resulting in production of antibodis
Both CD4+ and CD8+ T cells are involved Only TH cells are involved
Provides immunological surveillance and immunity against cancer No major role in immunological surveillance
Participates in rejection of homografts and graftversus- host reaction May be involved in early graft rejection due to preformed antibodies

Cell mediated immunity vs Humoral immunity

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